Desmoglein as a Target in Skin Disease and Beyond
نویسندگان
چکیده
منابع مشابه
Desmoglein as a target in skin disease and beyond
Much of the original research on desmosomes and their biochemical components was through analysis of skin and mucous membranes. The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes, desmogleins, and human diseases. The clinical and ...
متن کاملDesmoglein 1 and desmoglein 3 are the target autoantigens in herpetiform pemphigus.
OBJECTIVE To determine the cell surface autoimmune target of herpetiform pemphigus (HP). DESIGN Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg. PATIENTS Twenty serum samples were obtained from patients with HP wh...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2012
ISSN: 0022-202X
DOI: 10.1038/jid.2011.390